| Molecular Formula | C21H22F2N6O2 |
| Molar Mass | 428.4352 |
| Density | 1.55±0.1 g/cm3(Predicted) |
| Solubility | DMSO: ≥ 4.6 mg/mL |
| Appearance | morphological solid |
| Color | Yellow |
| pKa | 8.41±0.40(Predicted) |
| Storage Condition | Room Temprature |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 2 months. |
| Physical and Chemical Properties | Bioactive Larotrectinib (Vitrakvi, LOXO-101, ARRY-470) is a highly selective inhibitor of ATP-competitive, orally administered tropomyosin-related kinase (TRK) family receptors. |
| Downstream Products | LOXO-101 (sulfate) |
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.334 ml | 11.67 ml | 23.341 ml |
| 5 mM | 0.467 ml | 2.334 ml | 4.668 ml |
| 10 mM | 0.233 ml | 1.167 ml | 2.334 ml |
| 5 mM | 0.047 ml | 0.233 ml | 0.467 ml |
| Solubility | Soluble in DMSO (up to 5 mg/ml). |